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Benzene phosphorus thiamine

Product Name: Benzene phosphorus thiamine
CAS No.: 22457-89-2
Molecular Formula: C19H23N4O6PS
Molecular Weight: 466.45
Structural formula:
Density 1. 444 g/mL at 25 °C
Boiling point 745.1 °C (20 mmHg)
Flash point 404.4°C
Assay 98.0-102.0%
Appearance white or almost white crystalline powder
Application Benzene phosphorus thiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect. Benzene phosphorus thiamine already in the United States, Japan, Europe and other parts of the world wide market, its dosage forms listed dosage forms such as tablets, granules, indications are
A. is used for the prevention and treatment of vitamin B1 deficiency;
B. for vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during strenuous manual labor, etc.);
C. is used in the treatment of non alcoholic wernicke encephalopathy;
D. to treat beriberi;
E. used in the following diseases, speculation and vitamin B1 deficiency and metabolic disorders associated with treatment, such as neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other gastrointestinal motor function obstacle.
Test Item Analysis Specification
Description White to almost white crystal
Identification A: IR spectra shows the similarity between sample and standard
B: The retention time of the major peak corresponds with it of the reference standard
Solution color and clearness Colorless to pale-yellow clear solution
Chlorides Not more than 0.053%
Sulphate Not more than 0.011%
Loss on drying Not more than 1.5%
Heavy metals Not more than 0.002%
Related Substances TMP :Not more than 0.15%
Benzoic acid :not more than0.1%
Amide: not more than 0.40%
Single unknown impurity: not more than0.1%
Thiamine: not more than0.1%
Total impurities: Not more than 1.5%
Residual solvents Dichloromethane: not more than 600ppm
Isopropanol: not more than300ppm
Microbial limits Total bacteria: not more than100cfu/g
Yeast and mould: not more than50cfu/g
Escherichia coli: no detectable
Assay(Dry Basis) 98.0%-102.0%
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